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Simultaneous administration of cytarabine and methotrexate is associated with increased retention of ara-ctp within the cell.

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interaction with methotrexate concomitant use with ppis may elevate and or prolong serum concentrations of methotrexate and or its metabolite, possibly leading to toxicity.

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the fda recommends that methotrexate not be used in women of childbearing age unless there is clear medical evidence that the benefits can be expected to outweigh the considered risks.

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